Mississippi County Vacation Packages

Book a Hotel + Flight or Car together to unlock savings

  • Plan, book, travel with confidence

  • Better together

    Save up to CA $4,200 when you book a flight and hotel together*

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    With over 300,000 hotels worldwide, it's easy to create a perfect package

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Your Mississippi County Vacation

Book a vacation package to Mississippi County and make planning your adventure easy. With all the logistics arranged before you depart, you can focus on enjoying every minute in this exciting destination. A trip to Mississippi County promises plenty to see and do. Not sure where to start? Charleston is one of the most popular cities to stay here. Stop dreaming and start packing, because your Mississippi County vacation is only clicks away with Expedia.

Top Mississippi County Vacation Deals

Price found within the past 48 hours. Click for updated prices.
Drury Plaza Hotel Cape Girardeau Conference Center

Drury Plaza Hotel Cape Girardeau Conference Center

3 out of 5
Price was CA $1,139, price is now CA $1,043 per person
CA $1,043
per person
Sep 30 - Oct 5
found 5 hours ago
Roundtrip flight included
Toronto (YTO) to Cape Girardeau (CGI)
9.6/10 Exceptional! (1,011 reviews)
We really enjoy staying here. It's clean, beds are comfortable. Breakfast is very goods and lots of choices.

Reviewed on Jul 7, 2026

Mississippi County Hotel Deals

Super 8 by Wyndham Charleston/Sikeston East MO

Super 8 by Wyndham Charleston/Sikeston East MO

2 out of 5
310 S Story St Charleston MO
Fully refundableReserve now, pay when you stay
The price is CA $84 per night from Jul 19 to Jul 20
CA $84
CA $94 total
Jul 19 - Jul 20
includes taxes & fees
6.6/10 (647 reviews)
"Does NOT have smoking rooms. You can book one but they don’t have ANY for several months now. My room was recently renovated so it was fairly clean but no chair or ice bucket but the ice machine was out of order. Breakfast is a granola bar and coffee or an apple."

Reviewed on Jul 7, 2026

Super 8 by Wyndham Charleston/Sikeston East MO
The Riverstone Hotel Charleston-Sikeston

The Riverstone Hotel Charleston-Sikeston

2.5 out of 5
102 Drake St Charleston MO
Fully refundableReserve now, pay when you stay
The price is CA $106 per night from Jul 12 to Jul 13
CA $106
CA $118 total
Jul 12 - Jul 13
includes taxes & fees
6.8/10 (419 reviews)
"Wanted to use the pool, but had debris on the bottom and no (0) chairs to sit in."

Reviewed on Jul 7, 2026

The Riverstone Hotel Charleston-Sikeston
Drury Inn & Suites Sikeston, MO

Drury Inn & Suites Sikeston, MO

3 out of 5
2608 East Malone Ave, Miner Sikeston MO
Fully refundableReserve now, pay when you stay
The price is CA $157 per night from Jul 29 to Jul 30
CA $157
CA $181 total
Jul 29 - Jul 30
includes taxes & fees
9.6/10 Exceptional! (1,012 reviews)
"My wife and I are traveling and found your hotel to be one of the best where we stay. The staff was extremely friendly, helpful, courteous, and kind. They represented the company well stay there again."

Reviewed on Jul 9, 2026

Drury Inn & Suites Sikeston, MO
See all 112 properties in Mississippi County
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
All Inclusive Vacations
All Inclusive Vacations
Beach Vacations
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Family Vacations
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Frequently asked questions

How much does a Mississippi County vacation package cost?
The most affordable Mississippi County package is CA $1,043, so your dream getaway can become a reality — without spending an arm and a leg. Bundle flights, hotels, car rentals and more to create a package that matches your traveling style.
How do I get a cheap travel package to Mississippi County?
You'll save piles of cash if you bundle your flights, hotels and car rentals into a Mississippi County vacation package. Sometimes cheap means fewer options. But not with Expedia. We offer more than 550 partner airlines and 1,000,000 hotels across the world, so you'll always have plenty of variety to choose from. Want to save even more? Add some interesting activities to your package deal to unlock even more bargains! After all, travel is about more than simply getting to your destination.
What are the top hotels in Mississippi County?
East Prairie is one destination that most visitors to Mississippi County put on their itinerary. For a comfortable stay here, look up Super 8 by Wyndham Charleston MO and Quality Inn Charleston I-57.
How far in advance should I book my Mississippi County vacation?
Browse Expedia to compare airfares as soon as possible. In many cases, you can purchase a ticket up to 12 months prior to departure. If you don't see your preferred carrier, or you have to book last minute, fear not. Cheap fares to Mississippi County occasionally appear just weeks before the date of departure.
What does an Expedia Mississippi County travel package include?
That depends on what you're looking for. If you're traveling alone, you might decide to combine hotels and flights. Bringing the whole crew to Mississippi County? A travel package including rental cars, flights and hotels might be a better fit. Expedia gives you the flexibility to build your own travel package.
What should I know before booking a Mississippi County travel package?
You'll enjoy amazing savings when you combine your flights, hotels and rental cars into a package. Plus, booking everything together will make your trip planning easier. So why waste your money or time? Whether you're organizing a luxury romantic escape or a budget solo adventure, explore our vacation packages today.
Can I choose my airline with a Mississippi County Expedia vacation package?
Yes — that's the beauty of an Expedia package. You're the boss! We have access to more than 550 airline partners around the world, so you have loads of choice when organizing your Mississippi County adventure.
If I'm not able to travel, can I cancel my Mississippi County vacation package?
Yes, you can. We totally understand that even the best-laid plans can fail, so we're happy to help if you have to make changes to your Mississippi County vacation package. It may be possible to cancel or amend your itinerary at no cost if you've booked within 24 hours. Your airline, hotel or car rental company may impose a fee if your booking was made more than 24 hours ago. Head to our Customer Service Portal for further information. Also, be sure to check your itinerary for the nitty-gritty on change fees.

Stay near popular Mississippi County attractions

Big Oak Tree State Park

8.0/10 (20 reviews)
You can take time to visit Big Oak Tree State Park during your travels to East Prairie. While you're in the area, wander around the parks.
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* Savings based on package bookings compared to the price of the same components booked separately. Savings not available on all packages.